Oligodendrocyte Cell Line OLP6 Successfully Differentiates on Decellularized Brain Tissue

Objectives The mechanisms of mental and neurological diseases have been proposed to be related not only disorders the neurons but also environment surrounding neurons, such as glial cells extracellular matrix (ECM). chondroitin sulfate (CS) chain, which comprises CS proteoglycans (CSPGs), is one major sulfated glycosaminoglycans in brain. CSPGs play an important role development, aging, pathological conditions central nervous system. In particular, critical roles oligodendrocyte differentiation cell activity. Conventional two-dimensional culture a glass chamber hardly replicates complexity ECM structure or mimics vivo conditions. Therefore, solve this issue, study aimed use system with decellularized tissue scaffold organized ECM, thereby enabling observation interactions between ECM.